- Title
- Allogeneic hematopoietic cell transplantation for mycosis fungoides and Sezary syndrome
- Creator
- Lechowicz, M. J.; Lazarus, H. M.; Freytes, C. O.; Miller, A. M.; Vose, J. M.; Maziarz, R. T.; Montoto, S.; Maloney, D. G.; Hari, P. N.; Carreras, J.; Laport, G. G.; Cutler, C. S.; Wiernik, P. H.; Hale, G. A.; Maharaj, D.; Gale, R. P.; Rowlings, P. A,
- Relation
- Bone Marrow Transplantation Vol. 49, Issue 11, p. 1360-1365
- Publisher Link
- http://dx.doi.org/10.1038/bmt.2014.161
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2014
- Description
- We describe outcomes after allogeneic hematopoietic cell transplantation (HCT) for mycosis fungoides and Sezary syndrome (MF/SS). Outcomes of 129 subjects with MF/SS reported to the Center for the International Blood and Marrow Transplant from 2000-2009. Median time from diagnosis to transplant was 30 (4-206) months and most subjects were with multiply relapsed/ refractory disease. The majority (64%) received non-myeloablative conditioning (NST) or reduced intensity conditioning (RIC). NST/RIC recipients were older in age compared with myeloablative recipients (median age 51 vs 44 years, P=0.005) and transplanted in recent years. Non-relapse mortality (NRM) at 1 and 5 years was 19% (95% confidence interval (CI) 12-27%) and 22% (95% CI 15-31%), respectively. Risk of disease progression was 50% (95% CI 41-60%) at 1 year and 61% (95% CI 50-71%) at 5 years. PFS at 1 and 5 years was 31% (95% CI 22-40%) and 17% (95% CI 9-26%), respectively. OS at 1 and 5 years was 54% (95% CI 45-63%) and 32% (95% CI 22-44%), respectively. Allogeneic HCT in MF/SS results in 5-year survival in approximately one-third of patients and of those, half remain disease-free.
- Subject
- hematopoietic cell transplantation; HCT; Sezary syndrome; MF/SS; cutaneuos T-cell lymphoma
- Identifier
- http://hdl.handle.net/1959.13/1304759
- Identifier
- uon:20917
- Identifier
- ISSN:0268-3369
- Language
- eng
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